Huston became the third generation of her family to win an Academy Award, for her performance in 1985's Prizzi's Honor, joining her father, director John Huston, and grandfather, actor Walter Huston. She later was nominated in 1989 and 1990 for her acting in Enemies, a Love Story and The Grifters respectively. Among her roles, she starred as Morticia Addams in The Addams Family (1991) and Addams Family Values (1993), receiving Golden Globe nominations for both. Huston also played the Grand High Witch in the children's movie The Witches in 1990 and is, more recently, known for her frequent collaborations with director Wes Anderson. She has done voice work for the Tinker Bell series.