She was born in California and went to North Carolina School of the Arts. After she graduated, she moved to New York City to begin her career. She began her acting career on Broadway, most recently playing Cecile Leroux in Mark Twain's Is He Dead?.
Since 2006, she has progressed to several movies and television shows. Her filmography includes The Wedding Album, Blinders, Supreme Courtships, The Babysitters, and, most recently, the Sex and the City movie. She also had roles in the following TV shows: Love Monkey, Law & Order: Criminal Intent, American Experience, Six Degrees, The Black Donnellys, and New Amsterdam.
Bridget Regan is currently filming Legend of the Seeker, the television show based on Terry Goodkind's Sword of Truth series. She has one of the leading roles in the story, as Mother Confessor Kahlan Amnell.